Transcriptomic analysis identifies lactoferrin-induced quiescent circuits in neonatal macrophages.

ABSTRACT:

Introduction

Upon birth, a hitherto naïve immune system is confronted with a plethora of microbial antigens due to intestinal bacterial colonization. To prevent excessive inflammation and disruption of the epithelial barrier, physiological mechanisms must promote immune-anergy within the neonatal gut. As high concentrations of human lactoferrin (hLF), a transferrin glycoprotein shown to modulate macrophage function, are frequently encountered in colostrum, its direct interaction with intestinal macrophages may satisfy this physiological need. Thus, the primary objective of this study was to investigate transcriptional changes induced by human lactoferrin in neonatal monocyte-derived macrophages.

Methods

Cord blood-derived monocytes were differentiated with M-CSF in presence

SUBMITTER: Eigenschink M 

PROVIDER: S-EPMC10590118 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature