Intratracheal instillation of respirable particulate matter elicits neuroendocrine activation.

ABSTRACT:

Objective

Inhalation of ozone activates central sympathetic-adrenal-medullary and hypothalamic-pituitary-adrenal stress axes. While airway neural networks are known to communicate noxious stimuli to higher brain centers, it is not known to what extent responses generated from pulmonary airways contribute to neuroendocrine activation.

Materials and methods

Unlike inhalational exposures that involve the entire respiratory tract, we employed intratracheal (IT) instillations to expose only pulmonary airways to either soluble metal-rich residual oil fly ash (ROFA) or compressor-generated diesel exhaust particles (C-DEP). Male Wistar-Kyoto rats (12-13 weeks) were IT instilled with either saline, C-DEP or ROFA (5 mg/kg) and necropsied at 4 or 24 hr to assess temporal effects.

Re

SUBMITTER: Alewel DI 

PROVIDER: S-EPMC10590194 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature