Comprehensive analysis of CPSF4-related alternative splice genes in hepatocellular carcinoma.

ABSTRACT:

Background

An important stage in controlling gene expression is RNA alternative splicing (AS), and aberrant AS can trigger the development and spread of malignancies, including hepatocellular carcinoma (HCC). A crucial component of AS is cleavage and polyadenylation-specific factor 4 (CPSF4), a component of the CPSF complex, but it is unclear how CPSF4-related AS molecules describe immune cell infiltration in the total tumor microenvironment (TME).

Methods

Using RNA-sequencing data and clinical data from TCGA-LIHC from the Cancer Genome Atlas (TCGA) database, the AS genes with differential expression were found. The univariate Cox analysis, KM analysis, and Spearman analysis were used to identify the AS genes related to prognosis. Screening of key AS genes that are highly co

SUBMITTER: Yuemaierabola A 

PROVIDER: S-EPMC10590311 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature