Continuous multiplexed population representations of task context in the mouse primary visual cortex.

ABSTRACT: Effective task execution requires the representation of multiple task-related variables that determine how stimuli lead to correct responses. Even the primary visual cortex (V1) represents other task-related variables such as expectations, choice, and context. However, it is unclear how V1 can flexibly accommodate these variables without interfering with visual representations. We trained mice on a context-switching cross-modal decision task, where performance depends on inferring task context. We found that the context signal that emerged in V1 was behaviorally relevant as it strongly covaried with performance, independent from movement. Importantly, this signal was integrated into V1 representation by multiplexing visual and context signals into orthogonal subspaces. In addition, auditor

SUBMITTER: Hajnal MA 

PROVIDER: S-EPMC10590415 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature