The involvement of caspases in the process of nuclear removal during lens fiber cell differentiation.

ABSTRACT: The terminal differentiation of lens fiber cells involves elimination of their organelles, which must occur while still maintaining their functionality throughout a lifetime. Removal of non-nuclear organelles is accomplished through induction of autophagy following the spatiotemporal suppression of the PI3K/Akt signaling axis. However, blocking this pathway is not alone sufficient to induce removal of fiber cell nuclei. While the final steps in fiber cell nuclear elimination are highlighted by the appearance of TUNEL-positive nuclei, which are associated with activation of the lens-specific DNaseIIβ, there are many steps in the process that precede the appearance of double stranded DNA breaks. We showed that this carefully regulated process, including the early changes in nuclear morpholog

SUBMITTER: Gheyas R 

PROVIDER: S-EPMC10590423 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature