Remimazolam tosylate's long-term sedative properties in ICU patients on mechanical ventilation: effectiveness and safety.

ABSTRACT:

Objective

This study compared remimazolam tosylate with propofol or midazolam to assess its safety and effectiveness for long-term sedation of intensive care unit (ICU) patients requiring mechanical ventilation.

Methods

Adult patients in the ICU receiving sedation and mechanical ventilation for longer than 24 h were included in this single-center, prospective, observational study. Depending on the sedatives they were given, they were split into two groups (midazolam or propofol group; remimazolam group). ICU mortality was the main result. Laboratory tests, adverse events, and the length of ICU stay were considered secondary outcomes.

Results

A total of 106 patients were involved (46 received propofol or midazolam versus 60 received remimazolam). Age (P = 0.182), gende

SUBMITTER: Yao Z 

PROVIDER: S-EPMC10590506 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature