Development and validation of prognostic nomograms for early-onset colon cancer in different tumor locations: a population-based study.

ABSTRACT:

Objective

The prevalence of early-onset colon cancer (EOCC) among individuals below the age of 50 has shown a marked upward trend in recent years. The embryology, clinical symptoms, incidence, molecular pathways, and oncologic outcomes differ between right-sided and left-sided colon cancers. However, the differences have not been fully researched in EOCC. Our study aims to develop and validate prognostic nomograms predicting overall survival (OS) and cancer-specific survival (CSS) for EOCC in different tumor locations based on the Surveillance, Epidemiology, and End Results (SEER) database.

Methods

Using the SEER database, a total of 5,588 patients with EOCC were extracted and divided into development and validation cohorts in a random allocation ratio of 7:3 across three gr

SUBMITTER: Zhu S 

PROVIDER: S-EPMC10590526 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature