Vocal fold restoration after scarring: biocompatibility and efficacy of an MSC-based bioequivalent.

ABSTRACT:

Background

There is growing interest to application of regenerative medicine approaches in otorhinolaryngological practice, especially in the framework of the therapy of vocal fold (VF) scar lesions. The used conservative and surgical methods, despite the achieved positive outcomes, are frequently unpredictable and do not result in the restoration of the VF's lamina propria's structure, which provides the mechanical properties necessary for vibration. In this connection, the aim of this study was to ascertain the safety and efficacy of a bioequivalent in the treatment of VF scars using a rabbit model of chronic damage.

Methods

The bioequivalent consisted of a hydrogel system based on a PEG-fibrin conjugate and human bone marrow-derived MSC. It was characterized and implanted

SUBMITTER: Svistushkin M 

PROVIDER: S-EPMC10590531 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature