Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy.

ABSTRACT:

Aims

Diabetic retinopathy (DR) is a significant global public health concern. Alternative, safe, and cost-effective pharmacologic approaches are warranted. We aimed to investigate the therapeutic potential of nattokinase (NK) for early DR and the underlying molecular mechanism.

Methods

A mouse model of diabetes induced by streptozotocin was utilized and NK was administered via intravitreal injection. Microvascular abnormities were evaluated by examining the leakage from blood-retinal barrier dysfunction and loss of pericytes. Retinal neuroinflammation was examined through the assessment of glial activation and leukostasis. The level of high mobility group box 1 (HMGB1) and its downstream signaling molecules was evaluated following NK treatment.

Results

NK administrati

SUBMITTER: Huang Z 

PROVIDER: S-EPMC10590680 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature