Dual-response of multi-functional microsphere system to ultrasound and microenvironment for enhanced bone defect treatment.

ABSTRACT: Using bone tissue engineering strategies to achieve bone defect repair is a promising modality. However, the repair process outcomes are often unsatisfactory. Here we properly designed a multi-functional microsphere system, which could deliver bioactive proteins under the dual response of ultrasound and microenvironment, release microenvironment-responsive products on demand, reverse bone injury microenvironment, regulate the immune microenvironment, and achieve excellent bone defect treatment outcomes. In particular, the MnO₂ introduced into the poly(lactic-co-glycolic acid) (PLGA) microspheres during synthesis could consume the acid produced by the degradation of PLGA to protect bone morphogenetic protein-2 (BMP-2). More importantly, MnO₂ could consume reactive oxyg

SUBMITTER: Song Q 

PROVIDER: S-EPMC10590728 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature