A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke-induced neutrophilic and eosinophilic airway inflammation.

ABSTRACT:

Background

Air pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced inflammation.

Objective

The objective of this study was to determine whether γ-tocopherol would prevent experimental wood smoke-induced airway inflammation in humans.

Methods

This was a randomized, placebo-controlled clinical trial testing the effect of a short course of γ-tocopherol-enriched supplementation on airway inflammation following a controlled exposure to wood smoke particulates.

Results

Short-course γ-tocopherol intervention did not reduce wood smoke-induced neutrophilic airway inflammation, but it did

SUBMITTER: Peden DB 

PROVIDER: S-EPMC10590746 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature