CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions.

ABSTRACT: Prenylation is an irreversible post-translational modification that supports membrane interactions of proteins involved in various cellular processes, including migration, proliferation, and survival. Dysregulation of prenylation contributes to multiple disorders, including cancers and vascular and neurodegenerative diseases. Prenyltransferases tether isoprenoid lipids to proteins via a thioether linkage during prenylation. Pharmacological inhibition of the lipid synthesis pathway by statins is a therapeutic approach to control hyperlipidemia. Building on our previous finding that statins inhibit membrane association of G protein γ (Gγ) in a subtype-dependent manner, we investigated the molecular reasoning for this differential inhibition. We examined the prenylation of carboxy-terminus (C

SUBMITTER: Tennakoon M 

PROVIDER: S-EPMC10590752 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature