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Incidence of HER2-expressing brain metastases in patients with HER2-null breast cancer: a matched case analysis.

ABSTRACT: The HER2-directed antibody-drug conjugate trastuzumab deruxtecan is active against lower levels of HER2 expression than prior-generation therapies. The rate of HER2 expression in brain metastases among patients with initially HER2-null breast cancer is undefined, and receptor discordance in advanced breast cancer with brain metastases may underestimate CNS response potential in the absence of brain metastasis sampling. In this cohort study including 136 patients with 401 samples scored according to ASCO/CAP guidelines, 15/28 patients (54%) with HER2-null primary breast cancer have detectable HER2 expression in subsequently resected brain metastases, a significant discordant population.

SUBMITTER: Moss NS

PROVIDER: S-EPMC10590773 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Incidence of HER2-expressing brain metastases in patients with HER2-null breast cancer: a matched case analysis.

Moss Nelson S NS Singh Jolene M JM Reiner Anne S AS Drago Joshua Z JZ Modi Shanu S Seidman Andrew D AD Chandarlapaty Sarat S Ross Dara S DS

NPJ breast cancer 20231023 1

The HER2-directed antibody-drug conjugate trastuzumab deruxtecan is active against lower levels of HER2 expression than prior-generation therapies. The rate of HER2 expression in brain metastases among patients with initially HER2-null breast cancer is undefined, and receptor discordance in advanced breast cancer with brain metastases may underestimate CNS response potential in the absence of brain metastasis sampling. In this cohort study including 136 patients with 401 samples scored according ...[more]

PMID: 37867174

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