ERRα fosters running endurance by driving myofiber aerobic transformation and fuel efficiency.

ABSTRACT:

Objective

Estrogen related receptor α (ERRα) occupies a central node in the transcriptional control of energy metabolism, including in skeletal muscle, but whether modulation of its activity can directly contribute to extend endurance to exercise remains to be investigated. The goal of this study was to characterize the benefit of mice engineered to express a physiologically relevant activated form of ERRα on skeletal muscle exercise metabolism and performance.

Methods

We recently shown that mutational inactivation of three regulated phosphosites in the amino terminal domain of the nuclear receptor ERRα impedes its degradation, leading to an accumulation of ERRα proteins and perturbation of metabolic homeostasis in ERRα^3SA mutant mice. Herein, we used a multi-omic

SUBMITTER: Xia H 

PROVIDER: S-EPMC10590867 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature