Physical exercise elicits UPR^mt in the skeletal muscle: The role of c-Jun N-terminal kinase.

ABSTRACT:

Objective

The mitochondrial unfolded protein response (UPR^mt) is an adaptive cellular response to stress to ensure mitochondrial proteostasis and function. Here we explore the capacity of physical exercise to induce UPR^mt in the skeletal muscle.

Methods

Therefore, we combined mouse models of exercise (swimming and treadmill running), pharmacological intervention, and bioinformatics analyses.

Results

Firstly, RNA sequencing and Western blotting analysis revealed that an acute aerobic session stimulated several mitostress-related genes and protein content in muscle, including the UPR^mt markers. Conversely, using a large panel of isogenic strains of BXD mice, we identified that BXD73a and 73b strains displayed low levels of several UPR

SUBMITTER: Gaspar RS 

PROVIDER: S-EPMC10590869 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature