Immunotherapy and brain metastasis in lung cancer: connecting bench side science to the clinic.

ABSTRACT: Brain metastases (BMs) are the most common form of intracranial malignant neoplasms in adults, with a profound impact on quality of life and traditionally associated with a dismal prognosis. Lung cancer accounts for approximately 40%-50% of BM across different tumors. The process leading to BMs is complex and includes local invasion, intravasation, tumor cells circulation into the bloodstream, disruption of the blood-brain barrier, extravasation of tumor cells into the brain parenchyma, and interaction with cells of the brain microenvironment, among others. Once the tumor cells have seeded in the brain parenchyma, they encounter different glial cells of the brain, as well as immune cells. The interaction between these cells and tumor cells is complex and is associated with both antitumoral

SUBMITTER: Rios-Hoyo A 

PROVIDER: S-EPMC10590916 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature