Distinct effects of AMPAR subunit depletion on spatial memory.

ABSTRACT: Pharmacological studies established a role for AMPARs in the mammalian forebrain in spatial memory performance. Here we generated global GluA1/3 double knockout mice (Gria1/3^-/-) and conditional knockouts lacking GluA1 and GluA3 AMPAR subunits specifically from principal cells across the forebrain (Gria1/3^ΔFb). In both models, loss of GluA1 and GluA3 resulted in reduced hippocampal GluA2 and increased levels of the NMDAR subunit GluN2A. Electrically-evoked AMPAR-mediated EPSPs were greatly diminished, and there was an absence of tetanus-induced LTP. Gria1/3^-/- mice showed premature mortality. Gria1/3^ΔFb mice were viable, and their memory performance could be analyzed. In the Morris water maz

SUBMITTER: Eltokhi A 

PROVIDER: S-EPMC10590979 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature