Characterisation of topographical, biomechanical and maturation properties of corneocytes with respect to anatomical location.

ABSTRACT:

Background

The Stratum Corneum (SC) is the first barrier of the skin. The properties of individual cells are crucial in understanding how the SC at different anatomical regions maintains a healthy mechanical barrier. The aim of the current study is to present a comprehensive description of the maturation and mechanical properties of superficial corneocytes at different anatomical sites in the nominal dry state.

Materials and methods

Corneocytes were collected from five anatomical sites: forearm, cheek, neck, sacrum and medial heel of 10 healthy young participants. The surface topography was analysed using Atomic Force Microscopy (AFM) and Scanning Electron Microscopy (SEM). The level of positive-involucrin cornified envelopes (CEs) and desmoglein-1 (Dsg1) were used as indire

SUBMITTER: Evora AS 

PROVIDER: S-EPMC10591027 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature