Systems serology in cystic fibrosis: Anti-Pseudomonas IgG1 responses and reduced lung function.

ABSTRACT: Nearly one-half of patients with cystic fibrosis (CF) carry the homozygous F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene but exhibit variable lung function phenotypes. How adaptive immunity influences their lung function remains unclear, particularly the serological antibody responses to antigens from mucoid Pseudomonas in sera from patients with CF with varying lung function. Sera from patients with CF with reduced lung function show higher anti-outer membrane protein I (OprI) immunoglobulin G1 (IgG1) titers and greater antibody-mediated complement deposition. Induction of anti-OprI antibody isotypes with complement activity enhances lung inflammation in preclinical mouse models. This enhanced inflammation is absent in immunized Rag2^-/-

SUBMITTER: Lu S 

PROVIDER: S-EPMC10591031 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature