A 24-h restraint with food and water deprivation: a potential method to establish a model of depression in pigs.

ABSTRACT: Adverse stress, such as the long-term restriction of food intake and activity in intensive production, leads to a depression-like mental state in sows. Mood disorder, such as depression, is a widely concerned animal welfare issue. However, little is known about the biological mechanisms that underlie mood disorders in pigs. This study is the first attempt to establish a pig depression model by acute stress. A total of 16 adult Bama pigs were divided into the control and model groups, with 8 pigs (half male and half female) per group. The pigs in the model group were restrained for 24 h in a dark and ventilated environment, with food and water deprivation. After the restraint, behavioral tests (feed intake, sucrose preference test, open field test, and novel object test) were used to evalua

SUBMITTER: Yang S 

PROVIDER: S-EPMC10591077 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature