The kynurenine pathway presents multi-faceted metabolic vulnerabilities in cancer.
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ABSTRACT:
SUBMITTER: Leon-Letelier RA
PROVIDER: S-EPMC10591110 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
The kynurenine pathway presents multi-faceted metabolic vulnerabilities in cancer.
León-Letelier Ricardo A RA Dou Rongzhang R Vykoukal Jody J Sater Ali Hussein Abdel AHA Ostrin Edwin E Hanash Samir S Fahrmann Johannes F JF
Frontiers in oncology 20231009
The kynurenine pathway (KP) and associated catabolites play key roles in promoting tumor progression and modulating the host anti-tumor immune response. To date, considerable focus has been on the role of indoleamine 2,3-dioxygenase 1 (IDO1) and its catabolite, kynurenine (Kyn). However, increasing evidence has demonstrated that downstream KP enzymes and their associated metabolite products can also elicit tumor-microenvironment immune suppression. These advancements in our understanding of the ...[more]
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