Gut microbiota causally affects cholelithiasis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

The gut microbiota is closely linked to cholesterol metabolism-related diseases such as obesity and cardiovascular diseases. However, whether gut microbiota plays a causal role in cholelithiasis remains unclear.

Aims

This study explored the causal relationship between gut microbiota and cholelithiasis. We hypothesize that the gut microbiota influences cholelithiasis development.

Methods

A two-sample Mendelian randomization method was combined with STRING analysis to test this hypothesis. Summary data on gut microbiota and cholelithiasis were obtained from the MiBioGen (n=13,266) and FinnGen R8 consortia (n=334,367), respectively.

Results

Clostridium senegalense, Coprococcus3, and Lentisphaerae increased the risk of cholelithiasis

SUBMITTER: Liu X 

PROVIDER: S-EPMC10591199 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature