No causal association between COVID-19 and sepsis: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Sepsis and COVID-19 have a well-established observable relationship. Whether COVID-19 increases the likelihood of developing sepsis and whether patients with sepsis are at increased risk for COVID-19 infection is unknown. Using a bidirectional 2-sample Mendelian randomization (TSMR) analysis techniques in sizable cohorts, we sought to answer this question.

Methods

The current study performed Mendelian randomization (MR) on publicly accessible genome-wide association study (GWAS) summary data in order to investigate the causal linkages between COVID-19 and sepsis. A Two-Sample MR(TSMR) analyses was performed. As instrumental variables, a COVID-19 dataset of single nucleotide polymorphisms (SNPs) with significance value smaller than 5*10^-8 was employed an

SUBMITTER: Lu H 

PROVIDER: S-EPMC10591217 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature