Association between fibrosis-related gene polymorphism and long-term allograft outcome in renal transplant recipients.

ABSTRACT:

Background

Renal allograft fibrosis is one of characteristic causes of long-term renal function loss. The purpose of our study is to investigate the association between fibrosis-related genes single nucleotide polymorphism (SNPs) and kidney function in 5 years after kidney transplantation.

Methods

A total of 143 recipients were eligible for screening with 5-year follow-up information and SNP sequencing information from blood samples were included in this study. Minor Allele Frequency (MAF) and Hardy-Weinberg Equilibrium (HWE) analysis was conducted to identify tagger single-nucleotide polymorphisms (SNPs) and haplotypes. SNPs associated with the fifth year chronic kidney disease (CKD) staging were screened by SPSS and the "SNPassoc" package in RStudio and used for subsequent

SUBMITTER: Yin Y 

PROVIDER: S-EPMC10591404 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature