Identification of a basement membrane-related genes signature with immune correlation in bladder urothelial carcinoma and verification in vitro.

ABSTRACT:

Background

Bladder urothelial carcinoma (BLCA) is the most common genitourinary cancer and the prognosis of patients is often poor. However, studies of basement membrane-related genes (BM-related genes) in BLCA are less reported. Therefore, we established a BM-related genes signature to explore their functional and prognostic value in BLCA.

Methods

In this study, a BM-related genes signature was constructed by LASSO-Cox regression analysis, and then a series of bioinformatics methods was used to assess the accuracy and validity of the signature. We constructed a nomogram for clinical application and also screened for possible therapeutic drugs. To investigate the functions and pathways affected by BM-related genes in BLCA, we performed functional enrichment analyses. In addi

SUBMITTER: Li Y 

PROVIDER: S-EPMC10591420 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature