Modular Bioorthogonal Lipid Nanoparticle Modification Platforms for Cardiac Homing.

ABSTRACT: Lipid nanoparticles (LNPs) are becoming widely adopted as vectors for the delivery of therapeutic payloads but generally lack intrinsic tissue-homing properties. These extracellular vesicle (EV) mimetics can be targeted toward the liver, lung, or spleen via charge modification of their lipid headgroups. Homing to other tissues has only been achieved via covalent surface modification strategies using small-molecule ligands, peptides, or monoclonal antibodies─methods that are challenging to couple with large-scale manufacturing. Herein, we design a novel modular artificial membrane-binding protein (AMBP) platform for the modification of LNPs postformation. The system is composed of two protein modules that can be readily coupled using bioorthogonal chemistry to yield the AMBP. The first is a

SUBMITTER: Cruz-Samperio R 

PROVIDER: S-EPMC10591475 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature