NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity.

ABSTRACT: Chemical modifications in messenger RNA (mRNA) regulate gene expression and play critical roles in stress responses and diseases. Recently we have shown that N⁶-methyladenosine (m⁶A), the most abundant mRNA modification, promotes the repair of UVB-induced DNA damage by regulating global genome nucleotide excision repair (GG-NER). However, the roles of other mRNA modifications in the UVB-induced damage response remain understudied. N4-acetylcytidine (ac4C) is deposited in mRNA by the RNA-binding acetyltransferase NAT10. This NAT10-mediated ac4C in mRNA has been reported to increase both mRNA stability and translation. However, the role of ac4C and NAT10 in the UVB-induced DNA damage response remains poorly understood. Here we show that NAT10 plays a critical role in th

SUBMITTER: Yang Z 

PROVIDER: S-EPMC10591715 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature