Utilizing speech analysis to differentiate progressive supranuclear palsy from Parkinson's disease.

ABSTRACT:

Introduction

Distinguishing Parkinson's disease (PD) from Progressive supranuclear palsy (PSP) at early disease stages is important for clinical trial enrollment and clinical care/prognostication.

Methods

We recruited 21 participants with PSP(n = 11) or PD(n = 10) with reliable caregivers. Standardized passage reading, counting, and sustained phonation were recorded on the BioDigit Home tablet (BioSensics LLC, Newton, MA USA), and speech features from the assessments were analyzed using the BioDigit Speech platform (BioSensics LLC, Newton, MA USA). An independent t-test was performed to compare each speech feature between PSP and PD participants. We also performed Spearman's correlations to evaluate associations between speech measures and clinical scores (e.g., PSP rating s

SUBMITTER: Kang K 

PROVIDER: S-EPMC10591790 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature