A Bayesian statistics tutorial for clinical research: Prior distributions and meaningful results for small clinical samples.

ABSTRACT:

Objectives

Bayesian statistics provides an effective, reliable approach for research with small clinical samples and yields clinically meaningful results that can bridge research and practice. This tutorial demonstrates how Bayesian statistics can be effectively and reliably implemented with a small, heterogeneous participant sample to promote reproducible and clinically relevant research.

Methods/results

We tested example research questions pertaining to language and clinical features in autism spectrum disorder (ASD; n = 20), a condition characterized by significant heterogeneity. We provide step-by-step instructions and visualizations detailing how to (1) identify and develop prior distributions from the literature base, (2) evaluate model convergence and reliability, and

SUBMITTER: Larson C 

PROVIDER: S-EPMC10591806 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature