A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate.

ABSTRACT:

Background

Exposures to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), environmentally persistent chemicals detectable in the blood of most Americans, have been associated with several health outcomes. To offer insight into their possible biologic effects, we evaluated the metabolomic correlates of circulating PFOS and PFOA among 3,647 participants in eight nested case-control serum metabolomic profiling studies from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Methods

Metabolomic profiling was conducted by Metabolon Inc., using ultra high-performance liquid chromatography/tandem accurate mass spectrometry. We conducted study-specific multivariable linear regression analyses estimating the associations of metabolite levels with levels

SUBMITTER: Rhee J 

PROVIDER: S-EPMC10591812 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature