Elevated CRP and TNF-α levels are associated with blunted neural oscillations serving fluid intelligence.

ABSTRACT:

Introduction

Inflammatory processes help protect the body from potential threats such as bacterial or viral invasions. However, when such inflammatory processes become chronically engaged, synaptic impairments and neuronal cell death may occur. In particular, persistently high levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) have been linked to deficits in cognition and several psychiatric disorders. Higher-order cognitive processes such as fluid intelligence (Gf) are thought to be particularly vulnerable to persistent inflammation. Herein, we investigated the relationship between elevated CRP and TNF-α and the neural oscillatory dynamics serving Gf.

Methods

Seventy adults between the ages of 20-66 years (Mean = 45.17 years, SD = 16.29, 21.4% female

SUBMITTER: Dietz SM 

PROVIDER: S-EPMC10591904 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature