Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling.

ABSTRACT: The Hippo pathway is an evolutionarily conserved regulator of tissue growth that integrates inputs from both polarity and actomyosin networks. An upstream activator of the Hippo pathway, Kibra, localizes at the junctional and medial regions of the apical cortex in epithelial cells, and medial accumulation promotes Kibra activity. Here, we demonstrate that cortical Kibra distribution is controlled by a tug-of-war between apical polarity and actomyosin dynamics. We show that while the apical polarity network, in part via atypical protein kinase C (aPKC), tethers Kibra at the junctional cortex to silence its activity, medial actomyosin flows promote Kibra-mediated Hippo complex formation at the medial cortex, thereby activating the Hippo pathway. This study provides a mechanistic understandin

SUBMITTER: Tokamov SA 

PROVIDER: S-EPMC10591919 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature