ICAM-1-decorated extracellular vesicles loaded with miR-146a and <i>Glut1</i> drive immunomodulation and hinder tumor progression in a murine model of breast cancer.

ABSTRACT: Tumor-associated immune cells play a crucial role in cancer progression. Myeloid-derived suppressor cells (MDSCs), for example, are immature innate immune cells that infiltrate the tumor to exert immunosuppressive activity and protect cancer cells from the host's immune system and/or cancer-specific immunotherapies. While tumor-associated immune cells have emerged as a promising therapeutic target, efforts to counter immunosuppression within the tumor niche have been hampered by the lack of approaches that selectively target the immune cell compartment of the tumor, to effectively eliminate "tumor-protecting" immune cells and/or drive an "anti-tumor" phenotype. Here we report on a novel nanotechnology-based approach to target tumor-associated immune cells and promote "anti-tumor" responses

SUBMITTER: Duarte-Sanmiguel S 

PROVIDER: S-EPMC10591940 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature