Atrial Myopathy Quantified by Speckle-tracking Echocardiography in Mice.

ABSTRACT:

Background

Emerging evidence suggests that atrial myopathy may be the underlying pathophysiology that explains adverse cardiovascular outcomes in heart failure (HF) and atrial fibrillation. Lower left atrial (LA) function (strain) is a key biomarker of atrial myopathy, but murine LA strain has not been described, thus limiting translational investigation. Therefore, the objective of this study was to characterize LA function by speckle-tracking echocardiography in mouse models of atrial myopathy.

Methods

We used 3 models of atrial myopathy in wild-type male and female C57Bl6/J mice: (1) aged 16 to 17 months, (2) Ang II (angiotensin II) infusion, and (3) high-fat diet+Nω-nitro-_L-arginine methyl ester (HF with preserved ejection fraction, HFpEF). LA reservoir, condu

SUBMITTER: Zhang MJ 

PROVIDER: S-EPMC10591948 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature