Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype.

ABSTRACT: Currently, all salivary ducts (intercalated, striated and collecting) are assumed to function broadly in a similar manner, reclaiming ions that were secreted by the secretory acinar cells while preserving fluid volume and delivering saliva to the oral cavity. Nevertheless, there has been minimal investigation into the structural and functional differences between distinct types of salivary duct cells. Therefore, in this study, the expression profile of proteins involved in stimulus-secretion coupling, as well as the function of the intercalated duct (ID) and striated duct cells, was examined. Particular focus was placed on defining differences between distinct duct cell populations. To accomplish this, immunohistochemistry and in situ hybridization were utilized to examine the localization

SUBMITTER: Wahl AM 

PROVIDER: S-EPMC10591963 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature