Inflamed but not impulsive: Acute inflammatory cytokine response does not impact prepotent response inhibition.

ABSTRACT:

Background

Prior evidence has linked inflammation with impulsivity, but most of this evidence is cross-sectional. In this study, we provoked an acute inflammatory cytokine response to see whether it lowered prepotent response inhibition on three cognitive tasks.

Method

This study features secondary analyses from a randomized crossover trial in which 171 postmenopausal breast cancer survivors (Stage I-IIIA) each received a typhoid capsular polysaccharide vaccination and a saline placebo injection in a random sequence at two separate visits at least one month apart. Participants completed the Stroop Color-Discrepant Task, the 2-back, and the Conners Continuous Performance Test (CPT) on the computer between 5 and 7 h after the injections. They had their blood drawn once before

SUBMITTER: Madison AA 

PROVIDER: S-EPMC10591975 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature