Temporal trends and predictors of gestational exposure to organophosphate ester flame retardants and plasticizers.

ABSTRACT:

Background

Organophosphate esters (OPEs), used as flame retardants and plasticizers, are chemicals of concern for maternal and infant health. Prior studies examining temporal trends and predictors of OPE exposure are primarily limited by small sample sizes.

Objectives

Characterize temporal trends and predictors of OPE exposure biomarkers.

Methods

We determined urinary concentrations of eight biomarkers of OPE exposure at three timepoints during pregnancy for participants in the LIFECODES Fetal Growth Study (n = 900), a nested case-cohort recruited between 2007 and 2018. We examined biomarker concentrations, their variability during pregnancy, and temporal trends over the study period. In addition, we identified sociodemographic and pregnancy characteristics associated

SUBMITTER: Bommarito PA 

PROVIDER: S-EPMC10591987 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature