Predictors of successful anti-inflammatory drug trials in patients with schizophrenia: A meta-regression and critical commentary.

ABSTRACT: Given evidence pointing toward a role for immune dysregulation in the pathogenesis of schizophrenia, anti-inflammatory agents are promising adjunctive treatments that have potential to support a causal relationship for inflammation and psychopathology and lead to novel treatments for individuals. Indeed, previous meta-analyses have demonstrated small-to-medium effect sizes (ES) in favor of various anti-inflammatory agents, though there is significant heterogeneity and challenges in the interpretation of this literature. Identifying predictors, including sociodemographic variables, trial duration, and/or symptoms themselves, of successful anti-inflammatory trials may help identify which patients who might benefit from these compounds. We performed a meta-regression analysis of 63 adjunctive

SUBMITTER: Chandra A 

PROVIDER: S-EPMC10592013 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature