Probing the inhibitory motor circuits in adductor laryngeal dystonia during a dystonia-unrelated task.

ABSTRACT:

Background

The pathophysiology of adductor laryngeal dystonia (AdLD) remains unknown; however, there is growing evidence that dystonia is associated with disruptions in the inhibitory regulation of sensorimotor cortical areas. Using functional MRI (fMRI) and transcranial magnetic stimulation (TMS) complementarily, we previously demonstrated an overly activated laryngeal motor cortex and revealed correlations between blood-oxygen-level dependent (BOLD) activation and intracortical inhibition in a phonation (dystonia-related) task in adductor laryngeal dystonia (AdLD).

Objective

Here, we aimed to characterize the brain-based findings in the primary motor cortex (M1) during a dystonia-unrelated (finger tapping) task in AdLD and controls (CTL).

Methods

We examined the bet

SUBMITTER: Kuo YL 

PROVIDER: S-EPMC10592018 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature