Characterization of a commercial bioluminescence tomography-guided system for pre-clinical radiation research.

ABSTRACT:

Background

Widely used Cone-beam computed tomography (CBCT)-guided irradiators have limitations in localizing soft tissue targets growing in a low-contrast environment. This hinders small animal irradiators achieving precise focal irradiation.

Purpose

To advance image-guidance for soft tissue targeting, we developed a commercial-grade bioluminescence tomography-guided system (BLT, MuriGlo) for pre-clinical radiation research. We characterized the system performance and demonstrated its capability in target localization. We expect this study can provide a comprehensive guideline for the community in utilizing the BLT system for radiation studies.

Methods

MuriGlo consists of four mirrors, filters, lens, and charge-coupled device (CCD) camera, enabling a compact imaging

SUBMITTER: Xu X 

PROVIDER: S-EPMC10592094 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature