Longitudinal characterization of patients with progressive apraxia of speech without clearly predominant phonetic or prosodic speech features.

ABSTRACT: Most recent studies of progressive apraxia of speech (PAOS) have focused on patients with phonetic or prosodic predominant PAOS to understand the implications of the presenting clinical phenotype. Patients without a clearly predominating speech quality, or mixed AOS, have been excluded. Given the implications for disease progression, it is important to understand these patients early in the disease course to inform appropriate education and prognostication. The aim of this study was to describe a cohort of ten patients with initially mixed PAOS and how their clinical course evolves. Four patients were rated prosodic predominant later on (mild AOS at first visit); five were later designated phonetic (four with more than mild AOS at first visit); one was judged mixed at all visits. The study

SUBMITTER: Utianski RL 

PROVIDER: S-EPMC10592101 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature