Multiple sclerosis lesions that impair memory map to a connected memory circuit.

ABSTRACT:

Background

Nearly 1 million Americans are living with multiple sclerosis (MS) and 30-50% will experience memory dysfunction. It remains unclear whether this memory dysfunction is due to overall white matter lesion burden or damage to specific neuroanatomical structures. Here we test if MS memory dysfunction is associated with white matter lesions to a specific brain circuit.

Methods

We performed a cross-sectional analysis of standard structural images and verbal memory scores as assessed by immediate recall trials from 431 patients with MS (mean age 49.2 years, 71.9% female) enrolled at a large, academic referral center. White matter lesion locations from each patient were mapped using a validated algorithm. First, we tested for associations between memory dysfunction and to

SUBMITTER: Kletenik I 

PROVIDER: S-EPMC10592111 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature