Multi-omic responses of fish exposed to complex chemical mixtures in the Shenandoah River watershed.

ABSTRACT: To evaluate relationships between different anthropogenic impacts, contaminant occurrence, and fish health, we conducted in situ fish exposures across the Shenandoah River watershed at five sites with different land use. Exposure water was analyzed for over 500 chemical constituents, and organismal, metabolomic, and transcriptomic endpoints were measured in fathead minnows. Adverse reproductive outcomes were observed in fish exposed in the upper watershed at both wastewater treatment plant (WWTP) effluent- and agriculture-impacted sites, including decreased gonadosomatic index and altered secondary sex characteristics. This was accompanied with increased mortality at the site most impacted by agricultural activities. Molecular biomarkers of estrogen exposure were unchanged and consistent w

SUBMITTER: Bertolatus DW 

PROVIDER: S-EPMC10592118 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature