Sex differences in ethanol consumption and drinking despite negative consequences following adolescent social isolation stress in male and female rats.

ABSTRACT: Alcohol use disorder (AUD) is a debilitating psychiatric disorder characterized by drinking despite negative social and biological consequences. AUDs make up 71% of substance use disorders, with relapse rates as high as 80%. Current treatments stem from data conducted largely in males and fail to target the psychological distress motivating drinking in stress-vulnerable and at-risk populations. Here we employed a rat model and hypothesized that early life stress would reveal sex differences in ethanol intake and drinking despite negative consequences in adulthood. Rats were group housed or isolated postweaning to evaluate sex and stress effects on ethanol consumption in homecage drinking, self-administration (SA), and punished SA (drinking despite negative consequences) in adulthood. Stres

SUBMITTER: McElroy BD 

PROVIDER: S-EPMC10592127 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature