Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism.

ABSTRACT: In peroxisomes, acyl-CoA oxidase (ACOX) oxidizes fatty acids and produces H₂O₂, and the latter is decomposed by catalase. If ethanol is present, ethanol will be oxidized by catalase coupling with decomposition of H₂O₂. Peroxisome proliferator-activated receptor α (PPARα) agonist WY-14,643 escalated ethanol clearance, which was not observed in catalase knockout (Cat^-/-) mice or partially blocked by an ACOX1 inhibitor. WY-14,643 induced peroxisome proliferation via peroxin 16 (PEX16). PEX16 liver-specific knockout (Pex16^Alb-Cre) mice lack intact peroxisomes in liver, but catalase and ACOX1 were upregulated. Due to lacking intact peroxisomes, the upregulated catalase and ACOX1 in the Pex16^Alb-Cre mice were mislocated

SUBMITTER: Chen X 

PROVIDER: S-EPMC10592128 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature