Exploring molecular profiles of calcification in aortic vascular smooth muscle cells and aortic valvular interstitial cells.

ABSTRACT: Cardiovascular calcification can occur in vascular and valvular structures and is commonly associated with calcium deposition and tissue mineralization leading to stiffness and dysfunction. Patients with chronic kidney disease and associated hyperphosphatemia have an elevated risk for coronary artery calcification (CAC) and calcific aortic valve disease (CAVD). However, there is mounting evidence to suggest that the susceptibility and pathobiology of calcification in these two cardiovascular structures may be different, yet clinically they are similarly treated. To better understand diversity in molecular and cellular processes that underlie hyperphosphatemia-induced calcification in vascular and valvular structures, we exposed aortic vascular smooth muscle cells (AVSMCs) and aortic valve

SUBMITTER: Kessler JR 

PROVIDER: S-EPMC10592135 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature