Multifunctional Fiber-Based Optoacoustic Emitter as a Bidirectional Brain Interface.

ABSTRACT: A bidirectional brain interface with both "write" and "read" functions can be an important tool for fundamental studies and potential clinical treatments for neurological diseases. Herein, a miniaturized multifunctional fiber-based optoacoustic emitter (mFOE) is reported thatintegrates simultaneous optoacoustic stimulation for "write" and electrophysiology recording of neural circuits for "read". Because of the intrinsic ability of neurons to respond to acoustic wave, there is no requirement of the viral transfection. The orthogonality between optoacoustic waves and electrical field provides a solution to avoid the interference between electrical stimulation and recording. The stimulation function of the mFOE is first validated in cultured ratcortical neurons using calcium imaging. In vivo

SUBMITTER: Zheng N 

PROVIDER: S-EPMC10592200 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature