Cardiovascular health, infection burden, and incident dementia in the UK Biobank.

ABSTRACT:

Introduction

Among older adults, total and hospitalized infection may be associated with incidence of all-cause and Alzheimer's disease (AD) dementias, with variation by cardiovascular health (CVH).

Methods

We used Cox proportional hazards (PH) models to examine the relationships between International Classification of Diseases-10th revision (ICD-10)-specific viral and bacterial infectious agents and incident all-cause and AD dementia among 355,046 UK Biobank participants ≥50 years at baseline. Life's Essential 8 (LE8) index reflected CVH.

Results

In both sexes, total infection burden (yes vs. no) was associated with all-cause dementia, with significant interactions by LE8 tertiles, whereby this relationship was significant only in the lowest LE8 tertile. Hospital-tre

SUBMITTER: Beydoun HA 

PROVIDER: S-EPMC10592296 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature