Cobalt-Catalyzed Decarboxylative Allylations: Development and Mechanistic Studies.

ABSTRACT: In recent years, there has been a concerted drive to develop methods that are greener and more sustainable. Being an earth-abundant transition metal, cobalt offers an attractive substitute for commonly employed precious metal catalysts, though reactions engaging cobalt are still less developed. Herein, we report a method to achieve the decarboxylative allylation of nitrophenyl alkanes, nitroalkanes, and ketones employing cobalt. The reaction allows for the formation of various substituted allylated products in moderate-excellent yields with a broad scope. Additionally, the synthetic potential of the methodology is demonstrated by the transformation of products into versatile heterocyclic motifs. Mechanistic studies revealed an in situ activation of the Co(II)/dppBz precatalyst by the carbo

SUBMITTER: Joseph E 

PROVIDER: S-EPMC10592299 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature