White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer disease.

ABSTRACT:

Introduction

Vascular damage in Alzheimer's disease (AD) has shown conflicting findings particularly when analyzing longitudinal data. We introduce white matter hyperintensity (WMH) longitudinal morphometric analysis (WLMA) that quantifies WMH expansion as the distance from lesion voxels to a region of interest boundary.

Methods

WMH segmentation maps were derived from 270 longitudinal fluid-attenuated inversion recovery (FLAIR) ADNI images. WLMA was performed on five data-driven WMH patterns with distinct spatial distributions. Amyloid accumulation was evaluated with WMH expansion across the five WMH patterns.

Results

The preclinical group had significantly greater expansion in the posterior ventricular WM compared to controls. Amyloid significantly associated with fr

SUBMITTER: Strain JF 

PROVIDER: S-EPMC10592317 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature